The first two options provide the most comfortable gaming experience. You have four different difficulty options when you first play: Fortunately, with a few tweaks to your game settings, you can choose the best difficulty settings to make your The Witcher 3 experience enjoyable. It doesn't matter how you like to play, as long as you are having a good time.
You can go to The Witcher 3: Wild Hunt for the story, or you can experience it, experience grueling combat and balance the different oils and potions during combat.